Immune Response of Thalassemia Major Patients in Indonesia with and without Splenectomy

Authors

  • Teny T Sari1 Department of Pediatrics, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia
  • Djajadiman Gatot Department of Pediatrics, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia
  • Arwin A.P. Akib Department of Pediatrics, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia
  • Saptawati Bardosono Department of Clinical Nutrition, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital Jakarta, Indonesia
  • Sri R.S. Hadinegoro Department of Pediatrics, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
  • Alida R Harahap Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital Jakarta, Indonesia
  • Ponpon S Idjradinata Department of Child Health, Faculty of Medicine, Universitas Padjajaran - Hasan Sadikin Hospital, Bandung, Indonesia

Abstract

Aim: to describe non-spesific and specific immune response profile in Indonesian thalassemia major with and without splenectomy. Methods: this study was held at Thalassaemia Centre, Cipto Mangunkusumo Hospital Jakarta on September 2013 – February 2014. A comparative cross sectional study was conducted in healthy, thalassemia major aged more than 12 year and seronegative HIV. They were matched in age and sex for splenectomised and non-splenectomised groups, analysing the non-spesific immune response (neutrophil count and phagocytosis) and specific immune response (count and function of cellular immunity). Infection episodes were also analized as immune response in vivo parameter. Results: splenectomised thalassemia major showed increased neutrophil count but significantly decreased non-spesific immune response (neutrophil phagocytosis). Spesific immune response of splenectomised group presented significantly higher absolute lymphocyte, lymphocyte T, CD4+ and CD8+ counts compared to non-splenectomised thalassemia major (p<0.05). Ratio CD4+/CD8+ were similar in these groups. Serum marker of activated cellular imunity function (IL-2 and TNF-α) were similar among two groups. Mild infection episodes on splenectomised and non-splenectomised group were 2.02 (ranged 0 to 12) times and 0.81 (ranged 0 to 8) times (p=0.004), respectively. Severe infection on splenectomised group were sepsis for 2 weeks and diarrhea for 1 week, whereas on non-splenectomised group was typhoid fever for 4 days. Conclusion: there were significant differences on immune response among thalassemia major patients. Splenectomised thalassemia major showed a greater degree of susceptibility to infections than non-splenectomised thalassemia major. Key words: immune response, thalassemia major, splenectomy.

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Published

2016-05-16

How to Cite

Sari1, T. T., Gatot, D., Akib, A. A., Bardosono, S., Hadinegoro, S. R., Harahap, A. R., & Idjradinata, P. S. (2016). Immune Response of Thalassemia Major Patients in Indonesia with and without Splenectomy. Acta Medica Indonesiana, 46(3). Retrieved from https://www.actamedindones.org/index.php/ijim/article/view/91

Issue

Vol. 46 No. 3 (2014)

Section

ORIGINAL ARTICLE

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