The Effectiveness of Aerobic Exercise in Improving Peripheral Nerve Functions in Type 2 Diabetes Mellitus: An Evidence Based Case Report

Listya Tresnanti Mirtha, Viandini Permatahati


Background: peripheral neuropathy is known as one of most common complication in diabetes mellitus type 2 patient. This complication is caused by uncontrolled condition of blood glucose level in long periode. Regular physical activity in moderate to high intensity is beneficial in management of diabetes mellitus. This report aimed to know the effectiveness of aerobic exercise in causing improved peripheral functions in type 2 diabetes mellitus. Methods: literature searching using several related keywords in Medline®, Pubmed®, and Cochrane library, following inclusion and exclusion criteria. Results: Dixit et al suggested that a heart rate intensity of 40-60% aerobic exercise of 30–45 min duration per session for eight weeks suggest an important impact in controlling diabetic peripheral neuropathy. Kluding PM et al suggested that significantly improved selected measures of peripheral nerve function (“worst” pain levels and MNSI score), glycemic control (HbA1c), and resting heart rate. Conclusion: the studies showed significant benefit of aerobic exercise, despite the short duration of exercise being used as intervention towards improvement in peripheral nerve function. However, further studies with large samples and longer duration of intervention are needed to confirm the finding.


diabetes mellitus; neuropathy; aerobic exercise; HbA1c; evidence-based case report


Powers AC. Diabetes Melitus. In: Kasper DL, Hauser SL, Longo DL, Fauci AS, Jameson JL, Braunwald E. Harrison’s Principles of Internal Medicine. 16th ed. USA: McGraw-Hill; 2005. p. 830–5.

Lavery LA, Wunderlich RP, Tredwell JL. Disease management for the diabetic foot: effectiveness of a diabetic foot prevention program to reduce amputations and hospitalizations. Diabetes Res Clin Pract. 2005; 70:31–7.

Sims DS, Jr., Cavanagh PR, Ulbrecht JS. Risk factors in the diabetic foot. Recognition and management. Phys Ther. 1988; 68(12):1887–902.

Sinnreich, M., Taylor, B., & Dyck, P. J. (2005). Diabetic neuropathies: classification, clinical features, and pathophysiological basis. The Neurologist, 11, 63–79.

Perkumpulan Endokrinologi Indonesia. Konsensus pengelolaan dan pencegahan diabetes mellitus tipe 2 di Indonesia – 2015. Jakarta;PERKENI:2015

American Diabetes Association. Standards of medical care in diabetes—2015. Diabetes Care. 2015;38(1):1-93.

Church, T.S., LaMonte, M.J., Barlow, C.E., and Blair, S.N. Cardiorespiratory fitness and body mass index as predictors of cardiovascular disease mortality among men with diabetes. Arch Intern Med. 2005; 165: 2114–2210.

Moy, C.S., Songer, T.J., LaPorte, R.E. et al. Insulin-dependent diabetes mellitus, physical activity, and death. Am J Epidemiol. 1993; 137: 74–81.

Dixit S, et al. Effect of aerobic exercise on peripheral nerve functions of population with diabetic peripheral neuropathy in type 2 diabetes: A single blind, parallel group randomized controlled trial. Journal of Diabetes and Its Complications. 2014: 28; 332–9.

Kluding PM et al. The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy. Journal of Diabetes and Its Complications. 2012;26: 424–9.

Full Text: PDF


  • There are currently no refbacks.