Efficacy of Hyaluronic Acid in Radiation Proctitis: A Case Series

Authors

  • Marcellus Simadibrata Division of Gastroenterology, Pancreatobiliary, and Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General National Hospital, Jakarta, Indonesia.
  • Saskia Aziza Nursyirwan Division of Gastroenterology, Pancreatobiliary, and Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General National Hospital, Jakarta, Indonesia.
  • Rabbinu Rangga Pribadi Division of Gastroenterology, Pancreatobiliary, and Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General National Hospital, Jakarta, Indonesia.
  • Angelica Abigael Division of Gastroenterology, Pancreatobiliary, and Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General National Hospital, Jakarta, Indonesia.
  • Lidya Tanjaya Division of Gastroenterology, Pancreatobiliary, and Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General National Hospital, Jakarta, Indonesia.

Keywords:

radiation proctitis, hyaluronic acid, enema

Abstract

Gastrointestinal toxicities of radiation might develop after exposure, thus leading to conditions such as abdominal pain, rectal bleeding, diarrhea, anemia, and weight loss. The development of drugs to reduce mucosal damage progression has been a focus on managing radiation proctitis. Radiation proctitis resulting from exposure to pelvic radiotherapies is effectively managed with topical administration on the anal mucosa. The clinical use of hyaluronic acid offers an innovative approach to managing radiation injury. Hyaluronic acid has multiple beneficial properties, such as regulating immune process to reduce inflammation and oxidative stress, supporting natural protective mechanism, promoting mucosa healing, and improving tissue hydration. Therefore, this case series introduces the idea that application of hyaluronic acid could potentially improve patients’ clinical conditions.

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Published

2024-10-25

How to Cite

Simadibrata, M., Nursyirwan, S. A., Pribadi, R. R., Abigael, A., & Tanjaya, L. (2024). Efficacy of Hyaluronic Acid in Radiation Proctitis: A Case Series. Acta Medica Indonesiana, 56(3), 378. Retrieved from https://www.actamedindones.org/index.php/ijim/article/view/2515

Issue

Vol. 56 No. 3 (2024): Acta Medica Indonesiana

Section

CASE REPORT

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