COVID-19 Infection in Chronic Myeloid Leukemia Patients Receiving Tyrosine Kinase Inhibitor in Makassar, Indonesia: A Six-Case Report and Literature Review

Authors

  • Tutik Harjianti Division of Medical Hemato-oncology, Department of Internal Medicine, Hasanuddin University - Wahidin Sudirohusodo Teaching Hospital, Makassar, Indonesia
  • Fachruddin Benyamin Division of Medical Hemato-oncology, Department of Internal Medicine, Hasanuddin University - Wahidin Sudirohusodo Teaching Hospital, Makassar, Indonesia
  • Rahmawati Minhajat Division of Medical Hemato-oncology, Department of Internal Medicine, Hasanuddin University - Wahidin Sudirohusodo Teaching Hospital, Makassar, Indonesia
  • Sahyuddin Saleh Division of Medical Hemato-oncology, Department of Internal Medicine, Hasanuddin University - Wahidin Sudirohusodo Teaching Hospital, Makassar, Indonesia
  • Dimas Bayu Division of Medical Hemato-oncology, Department of Internal Medicine, Hasanuddin University - Wahidin Sudirohusodo Teaching Hospital, Makassar, Indonesia
  • Wahyudi Pababbari Division of Medical Hemato-oncology, Department of Internal Medicine, Hasanuddin University - Wahidin Sudirohusodo Teaching Hospital, Makassar, Indonesia

Keywords:

Chronic Myeloid Leukemia, Tyrosine Kinase Inhibitor, COVID-19, Case Report

Abstract

Management of chronic myeloid leukemia (CML) in patients who are infected with COVID-19 is a challenging task due to disease-related or treatment-related factors that place such patients at a higher risk of complications. However, a low-infectivity-rate mechanism has been proposed by some researchers. In CML patients with COVID-19 infection, the most important treatment-related factor involves tyrosine kinase inhibitors (TKIs). In this case report, six patients with chronic-phase CML who experienced COVID-19 of mild–moderate severity all continued to receive TKI treatment for CML concurrently with COVID-19 treatment. All patients fully recovered. In the present study, we also review four other cases of COVID-19 infection in CML patients. Outcomes for TKI-treated CML patients who contract COVID-19 are influenced by many factors. Tyrosine kinase inhibitor therapy may benefit CML patients due to its antiviral effect, but the interaction between TKIs and drugs used for COVID-19 treatment requires careful monitoring. An individual approach is needed in every case.

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Published

2023-11-01

How to Cite

Harjianti, T., Benyamin, F., Minhajat, R., Saleh, S., Bayu, D., & Pababbari, W. (2023). COVID-19 Infection in Chronic Myeloid Leukemia Patients Receiving Tyrosine Kinase Inhibitor in Makassar, Indonesia: A Six-Case Report and Literature Review. Acta Medica Indonesiana, 55(3), 332. Retrieved from https://www.actamedindones.org/index.php/ijim/article/view/2346