Effect of Cholecalciferol Supplementation on Disease Activity and Quality of Life of Systemic Lupus Erythematosus Patients: A Randomized Clinical Trial Study
Conclusion: Supplementation of cholecalciferol 5000 IU/day for 12 weeks was statistically significant in increasing vitamin D levels and improving disease activity, but did not significantly improve the quality of life of SLE patients.
Bertsias G RC. SLE pathogenesis and clinical feature. eular-fpp-indd. 2012;36(12):1503.
Olesińska M, Saletra A. Quality of life in systemic lupus erythematosus and its measurement. 2018;45–54.
Buleu F, Gurban C, Sarbu E, et al. The relationship between vitamin D, inflammation and the activity of systemic lupus erythematosus. Fiziol - Physiol. 2015;25(November):87.
Nguyen MH, Bryant K, O’Neill SG. Vitamin D in SLE: a role in pathogenesis and fatigue? A review of the literature. Lupus. 2018;27(13):2003–11.
Antico A, Tampoia M, Tozzoli R, Bizzaro N. Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature. Autoimmun Rev [Internet]. 2012;12(2):127–36.
Christie M, Bartels HSD. Systemic lupus erythematosus (SLE). Medscape [Internet]. 2020;2(2):2319–6718.
Hassanalilou1 T, Khalili L, Ghavamzadeh S, et al. Role of vitamin D defciency in systemic lupus erythematosus incidence and aggravation. Autoimmun Highlights. 2018;9(1):890–4.
Hassanalilou T, Khalili L, Ghavamzadeh S, et al. Role of vitamin D defciency in systemic lupus erythematosus incidence and aggravation. Autoimmun Highlights [Internet]. 2018;9(1):1–10.
Schoindre Y, Jallouli M, Tanguy ML, et al. Lower vitamin D levels are associated with higher systemic lupus erythematosus activity, but not predictive of disease flare-up. Lupus Sci Med. 2014;1(1):1–8.
Rifaâi, Kusworini A, Kusworini HKSW. Effect of vitamin D supplementation on disease activity (SLEDAI) and fatigue in Systemic Lupus Erythematosus patients with hipovitamin D: An Open Clinical Trial. Indones J Rheumatol. 2008;8(2):501–7.
Lomarat W, Narongroeknawin P, Chaiamnuay S, Asavatanabodee P. Randomized double-blind controlled trial to evaluate efficacy of vitamin d supplementation among patients. 2020;7980:24–32.
Fisher SA, Rahimzadeh M, Brierley C, et al. The role of vitamin D in increasing circulating T regulatory cell numbers and modulating T regulatory cell phenotypes in patients with inflammatory disease or in healthy volunteers: A systematic review. PLoS One. 2019;14(9):1–18.
McElhone K, Abbott J, Teh LS. A review of health related quality of life in systemic lupus erythematosus. Lupus. 2006;15(10):633–43.
Lima GL, Paupitz J, Aikawa NE, Takayama L, Bonfa E, Pereira RMR. Vitamin D supplementation in adolescents and young adults with juvenile systemic lupus erythematosus for improvement in disease activity and fatigue scores: a randomized, double-blind, placebo-controlled trial. Arthritis Care Res. 2016;68(1):91–8.
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