The Association Between Parents History of Type 2 Diabetes with Metabolic Syndrome Component and Insulin Resistance in Non-Diabetic Young Adult Male

Authors

  • A Makbul Aman Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia http://orcid.org/0000-0002-9342-4085
  • Haerani Rasyid Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Syakib Bakri Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Ilham J Patellongi Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

Keywords:

parent history of type 2 diabetes, metabolic syndrome, insulin resistance

Abstract

Background: the familial nature of type 2 diabetes is manifested by the presence of insulin resistance in non-diabetic first degree relatives. Most of these studies have been performed in middle-aged and there is only few published studies in young age individuals and adolescents. This study aimed to determine the relationship between parents history of type-2 diabetes with metabolic syndrome component and insulin resistance in adolescent non-diabetic subjects. Methods: this was a cross sectional study comparing the metabolic profile, risk of metabolic syndrome and insulin resistance in non-diabetic male adolescents (17-24 years old) whose one or both parents were with type-2 diabetes. We performed anamnesis, physical examination, fasting plasma glucose, lipid profile, fasting insulin level and insulin resistance based on HOMA-IR. Results: metabolic abnormalities were more prevalent in subjects whose parents were with history of type-2 diabetes, especially their waist circumference, fasting plasma glucose, triglyceride, fasting insulin and HOMA-IR (p=0.000). There was increased risk of developing central obesity in adolescents with parental history of 19.3 fold (95%CI 2.46-151.07) and insulin resistance of 10.3 fold (95%CI 3.89-27.23). Parental history of type-2 diabetes together with metabolic syndrome component ie. waist circumference >90 cm and triglyceride ≥150 mg/dl were strong determinat factors for insulin resistance (R2=50.7%). Conclusion: the early multiple metabolic defect can be detected in non-diabetes adolescents with parental history of type-2 diabetes. Cluster of metabolic syndrome component in these subject become  a powerful determinat factor for insulin resistance.

Author Biography

A Makbul Aman, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

internal medicine department, hasanuddin university

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Published

2019-01-11

How to Cite

Aman, A. M., Rasyid, H., Bakri, S., & Patellongi, I. J. (2019). The Association Between Parents History of Type 2 Diabetes with Metabolic Syndrome Component and Insulin Resistance in Non-Diabetic Young Adult Male. Acta Medica Indonesiana, 50(4), 309. Retrieved from https://www.actamedindones.org/index.php/ijim/article/view/732

Issue

Vol. 50 No. 4 (2018): Acta Medica Indonesiana

Section

ORIGINAL ARTICLE

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