Local Crude House Dust Extracts as a Substitute for Standardized House Dust Mite Extracts in Allergy Diagnostic and Immunotherapy

Authors

  • Odhi Anggani Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Sardjito General Hospital, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
  • Feri Trihandoko Department of Ear, Nose, Throat, Head and Neck Surgery, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
  • Almarissa Ajeng Prameshwara Microbiology Department, Faculty of Medicine and Health Sciences, Alma-Ata University

Keywords:

Local Crude House Dust Extracts, House Dust Mite, Skin Prick Test, Allergen Extracts, Allergen immunotherapy

Abstract

Allergic diseases are a significant global health issue commonly triggered by house dust mite (HDM) allergens. Standardized HDM extracts are currently widely used in allergen immunotherapy (AIT) and diagnostic tests. However, in several tropical regions, such as Indonesia, these standardized extracts were either expensive, difficult to obtain, or did not represent local allergen exposure. Previous studies examined crude house dust extracts (CHDE) derived from locally collected dust as a possible substitute because they reflected the complex allergenic and other composition of the local environment. Therefore, this study aimed to review the potential of Local Crude House Dust Extracts (LCHDE) as a regionally relevant substitute source of allergens for both diagnostic and therapeutic applications. LCHDE reflects real environmental exposure, including region-specific mite, fungal, and bacterial components, which could better represent local allergen profiles. LCHDE offered a promising, cost-effective, and contextually relevant option for allergy diagnosis in developing regions. However, its application in immunotherapy necessitated rigorous allergen profiling, and regional collaboration was crucial to establish a CHDE suitable for clinical use.

Author Biographies

Feri Trihandoko, Department of Ear, Nose, Throat, Head and Neck Surgery, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia

Biomedical Science department, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Almarissa Ajeng Prameshwara, Microbiology Department, Faculty of Medicine and Health Sciences, Alma-Ata University

Microbiology department, Faculty of Medicine and Health Sciences, Alma Ata University.

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Published

2026-07-03

How to Cite

Anggani, O. ., Trihandoko, F. ., & Prameshwara, A. A. . (2026). Local Crude House Dust Extracts as a Substitute for Standardized House Dust Mite Extracts in Allergy Diagnostic and Immunotherapy. Acta Medica Indonesiana, 58(2), 314. Retrieved from https://www.actamedindones.org/index.php/ijim/article/view/3232

Issue

Vol. 58 No. 2 (2026): Acta Medica Indonesiana

Section

CLINICAL PRACTICE

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Copyright (c) 2026 Odhi Anggani, Zahratul Aini, Almarissa Ajeng Prameshwara

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