Factors Affecting the Quality of Life of Patients After Kidney Transplantation: A Cross-Sectional Study
Abstract
Background: Kidney transplantation is currently the best choice for renal replacement therapy, due to its effect in reducing mortality and improving the quality of life (QoL) of patients with end-stage renal disease. This study aimed to identify factors affecting QoL after kidney transplantation. Methods: We conducted a cross sectional study by recruiting patients who had kidney transplantation at Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, from 2018 – 2020. QoL was assessed using the 36-item Short Form Health Survey (SF-36) questionnaire. We evaluated age, sex, body mass index, hemoglobin level, estimated glomerular filtration rate, duration of dialysis before transplantation, history of diabetes, depression, and performance status as factors associated with QoL score. Results: We involved 107 subjects in our study. Depression, hemoglobin level, ECOG performance status, and duration of dialysis were factors affecting the physical component score (R2=0.21). Depression and hemoglobin level were factors affecting the mental component score (R2=0.34 ). Depression, hemoglobin level, and ECOG performance status were factors contributed to the total QoL score (R2=0.41). Conclusion: Factors that contributed to QoL status were depression, ECOG performance status, and hemoglobin levels. This study supported the need for assessment of QoL on regular basis, psychological aspects including depression, as well as other factors that can affect QoL such as performance status and hemoglobin level in patients before and after kidney transplantations.
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References
Vos T, Lim SS, Abbafati C, et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396(10258):1204–22.
PERNEFRI. 11th report of Indonesian renal registry 2018. Indones Ren Regist. 2018;1–46.
Couser WG, Remuzzi G, Mendis S, et al. The contribution of chronic kidney disease to the global burden of major noncommunicable diseases. Kidney Int. 2011;80(12):1258–70.
Anjarwati A. Health related-quality of life in CKD and dialysis patients in Asian countries: A systematic review. ARKESMAS (Arsip Kesehat Masyarakat). 2018;3(2):50–5.
Dimova R, Keskinova D, Tzekov V, et al. Health-related quality of life in end-stage renal disease patients, using the missoula-vitas quality of life index: A multicenter study. Med Pharm Reports. 2019;92(4):374–81.
Chen SS, Al Mawed S, Unruh M. Health-related quality of life in end-stage renal disease patients: How often should we ask and what do we do with the answer? Blood Purif. 2016;41(1–3):218–24.
Yang F, Griva K, Lau T, et al. Health-related quality of life of Asian patients with end-stage renal disease (ESRD) in Singapore. Qual Life Res. 2015;24(9):2163–71.
De Mendonca AEO, Torres GDV, Salvetti MDG, et al. Changes in quality of life after kidney transplantation and related factors. Acta Paul Enferm. 2014;27(3):287–92.
Shirazian S, Grant CD, Aina O, et al. Depression in chronic kidney disease and end-stage renal disease: Similarities and differences in diagnosis, epidemiology, and management. Kidney Int Reports. 2017;2(1):94–107.
Cohen SD, Norris L, Acquaviva K, et al. Special feature: Primary care issues for the nephrologist screening, diagnosis, and treatment of depression in patients with end-stage renal disease. Am Soc Nephrol. 2007;10(15):1332–42.
Dąbrowska-Bender M, Dykowska G, Żuk W, et al. The impact on quality of life of dialysis patients with renal insufficiency. Dovepress. 2018;12:577–83.
Chan-on C, Sarwal MM. A comprehensive analysis of the current status and unmet needs in kidney transplantation in Southeast Asia. Front Med. 2017;4:1–14.
Kaballo MA, Canney M, O’Kelly P, et al. A comparative analysis of survival of patients on dialysis and after kidney transplantation. Clin Kidney J. 2018;11(3):389–93.
Kostro JZ, Hellmann A, Kobiela J, et al. Quality of life after kidney transplantation: A prospective study. Transplant Proc. 2016;48(1):50–4.
Finkelstein FO, Wuerth D, Finkelstein SH. Health related quality of life and the CKD patient: challenges for the nephrology community. Kidney Int. 2009;76(9):946–52.
Mouelhi Y, Jouve E, Alessandrini M, et al. Factors associated with health-related quality of life in kidney transplant recipients in France. BMC Nephrol. 2018;1–12.
Marbun MBH, Susalit E, Susilowati U, et al. Long-term outcomes and prognostic factors in kidney transplant recipients in Jakarta, Indonesia: a cohort study. BMJ Open. 2022;12(5):e059631.
Riley RD, Snell KIE, Ensor J, et al. Minimum sample size for developing a multivariable prediction model: Part I - Continuous outcomes. Stat Med. 2019;38(7):1262–75.
Saris-Baglama RN, Dewey CJ, Chisholm GB, et al. QualityMetric health outcomesTM scoring software 4.0: installation guide. Lincoln, RI: QualityMetric Incorporated; 2010. p. 138.
Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67(6):361–70.
Oken MM, Creech RH, Tormey DC, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982;5(6):649–55.
National Health Ministry of Indonesia. Situasi lanjut usia di Indonesia. Jakarta; 2016.
WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363(9403):157–63.
IBM Corp. IBM SPSS Statistics for Windows. Armonk, NY: IBM Corp; 2011.
Hwang Y, Kim M, Min K. Factors associated with health-related quality of life in kidney transplant recipients in Korea. PLoS One. 2021;16(3 March):1–13.
Matas AJ, Smith JM, Skeans MA, et al. OPTN/SRTR 2013 annual data report: Kidney. Am J Transplant. 2015;15:1–34.
Supit T, Nugroho EA, Santosa A, et al. Kidney transplantation in Indonesia: An update. Asian J Urol. 2019;6(4):305–11.
Shetty AA, Wertheim JA, Butt Z. Health-related quality of life outcomes after kidney transplantation. Kidney Transplantation, Bioeng Regen. 2017;699–708.
World Health Organization (WHO). Constitution of the World Health Organization. In: World Health Organization (WHO), editor. World Health Organization: Basic documents. 45th ed. Geneva: World Health Organization (WHO); 2005.
González-blanch C, Hernández-de-hita F, Muñoz-navarro R, et al. The association between different domains of quality of life and symptoms in primary care patients with emotional disorders. 2018;(June):1–10.
Theofilou P. Quality of life: Definition and measurement. Eur J Psychol. 2013;9(1):150–62.
Gentile S, Beauger D, Speyer E, et al. Factors associated with health-related quality of life in renal transplant recipients: results of a national survey in France. Health Qual Life Outcomes. 2013;11(1):88.
Griva K, Stygall J, Ng JH, et al. Prospective changes in health-related quality of life and emotional outcomes in kidney transplantation over 6 years. J Transplant. 2011;2011:1–12.
Widayanti AW, Green JA, Heydon S, et al. Health-seeking behavior of people in Indonesia: A narrative review. J Epidemiol Glob Health. 2020;10(1):6.
Huang I-C, Lee JL, Ketheeswaran P, et al. Does personality affect health-related quality of life? A systematic review. PLoS One. 2017;12(3):e0173806.
Cho S, Park S, Kim JE, et al. Incidence of depression in kidney transplant recipients in South Korea: a long-term population-based study. Sci Rep. 2022;12(1):17603.
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