HIV-Associated Progressive Multifocal Leukoencephalopathy: A Case Study

Elsayed Abed, Ahmed Farag El-adawey, Mohamed Hamed Rashad, Ahmed Essmat, Mohammed Ali, Ahmed Hassan Elsheshiny, Abdel-Ghaffar Fayed, Fathy Elbaz, Mahmoud Galal Ahmed, Zohreh Abna, Shaimaa Sayed Khater


Progressive multifocal leukoencephalopathy (PML) is a rare, life-threatening, infectious, lytic, demyelinating disease that results from reactivation of the virulent JC polyomavirus (JCV) “major opportunistic infection” in immunosuppressed individuals. We reported a case of a young girl who presented with new onset focal neurological defect, evaluated, and laboratory and radiological findings in the context of a clinical setting confirmed HIV-related-PML infection. However, remyelination does not occur, the patients may develop complications in the long term including cognitive impairment, sensory deficits, motor deficits, and disturbances in balance. We must increase our knowledge about HIV- related PML in any patient with reduced immunity and who presented with new onset neurological defect.



Progressive multifocal; leukoencephalopathy; JC virus; demyelinating disease


Major EO. Progressive multifocal leukoencephalopathy in patients on immunomodulatory therapies. Annual Review of Medicine. 2010;61:35-47.

Wüthrich C, Cheng YM, Joseph JT, et al. Frequent infection of cerebellar granule cell neurons by polyomavirus JC in progressive multifocal leukoencephalopathy. Journal of Neuropathology & Experimental Neurology. 2009;68(1):15-25.

Mancall EL. Ricahrdson EPJr. Progressive multifocal leukoencephalopathy: hitherto unrecognized complication of chronic lymphatic leukemia and Hodgkins disease. Brain. 1958;81:93-111.

Koralnik IJ. Progressive multifocal leukoencephalopathy revisited: has the disease outgrown its name? Annals of Neurology. 2006;60(2):162-73.

Choudhary S, Parashar MK, Parashar N, Ratre S. AIDS-related progressive multifocal leukoencephalopathy-really rare in India: A case report and review of literature. Indian Journal of Sexually Transmitted Diseases and AIDS. 2018;39(1):55.

Jensen N, Eugene O, Major P. A classification scheme for human polyomavirus JCV variants based on the nucleotide sequence of the noncoding regulatory region. Journal of Neurovirology. 2001;7(4):280-7.

Lima MA, Marzocchetti A, Autissier P, et al. Frequency and phenotype of JC virus-specific CD8+ T lymphocytes in the peripheral blood of patients with progressive multifocal leukoencephalopathy. Journal of Virology. 2007;81(7):3361-8.

Gildenberg PL, Gathe Jr, JC, Kim JH. Stereotactic biopsy of cerebral lesions in AIDS. Clinical Infectious Diseases. 2000;30(3):491-9.

Miller RF, Hall-Craggs MA, Costa DC, et al. Magnetic resonance imaging, thallium-201 SPET scanning, and laboratory analyses for discrimination of cerebral lymphoma and toxoplasmosis in AIDS. Sexually Transmitted Infections. 1998;74(4):258-64.

Clifford DB, Nath A, Cinque P, et al. A study of mefloquine treatment for progressive multifocal leukoencephalopathy: results and exploration of predictors of PML outcomes. Journal of Neurovirology,. 2013;19(4):351-8.

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