Insulin Resistance in Gastroesophageal Reflux Disease

Laras Budiyani, Dyah Purnamasari, Marcellus Simadibrata, Murdani Abdullah

Abstract


Insulin resistance is the disturbance of glucose regulation characterized by higher insulin level. In clinical context, insulin resistance can manifest as abnormalities that are related with cardiovascular event risk, known as metabolic syndrome. Several studies had reported that insulin resistance was associated with erosive esophagitis in patients with gastroesophageal reflux disease (GERD).

Keywords


insulin resistance; GERD; metabolic syndrome; erosive esophagitis

References


Wilcox G. Insulin and insulin resistance. Clin Biochem Rev. 2005;26:19-39.

Huang P. A comprehensive definition for metabolic syndrome. Dis Model Mech. 2009;2(5-6):231-7.

Badan Penelitian dan Pengembangan Kesehatan RI. Riset Kesehatan Dasar (Riskesdas). Jakarta:2013.

Soewondo P, Purnamasari D, Oemardi M, et al. Prevalence of metabolic syndrome using NCEP/ATP III criteria in Jakarta, Indonesia. The Jakarta primary noncommunicable disease risk factors surveillance 2006. Acta Med Indones. 2010:42 (4):199-203.

The Indonesian Society of Gastroenterology. National consensus on the management of gastroesophageal reflux disease in Indonesia. Acta Med Indones. 2014;46(3):263-71.

Badillo R, Francis D. Diagnosis and treatment of gastroesophageal reflux disease. World J Gastrointest Pharmacol Ther. 2014;5(3):105-12.

Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013;108:308–28.

Morino K, Petersen KF, Shulman GI. Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes. 2006;55(Suppl.2):S9-S15.

Saini V. Molecular mechanisms of insulin resistance in type 2 diabetes mellitus. World J Diabetes. 2010;1(3):68-75.

Abel ED, O’Shea KM, Ramasamy R. Insulin resistance: metabolic mechanisms and consequences in the Heart. Arterioscler Thromb Vasc Biol. 2012;32:2068-76.

Masharani U, German M. Pancreatic hormones and diabetes mellitus. Greenspan’s basic and clinical endocrinology. 9th ed. New York: McGraw-Hill; 2011. p. 590-2.

Borai A, Livingstone C, Kaddam I, Ferns G. Selection of the appropriate method for the assessment of insulin resistance. BMC Med Res Method. 2011;11:158.

Wallace T, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Dia Care. 2004;27(6):1487-95.

Yamada C, Moriyama C, Takahashi E. Optimal cut-off point for homeostasis model assessment of insulin resistance to discriminate metabolic syndrome in non-diabetic Japanese subjects. J Diabetes Invest. 2012;3(4):384-7.

Gosal F, Waleleng BJ, Pandelaki K. Hubungan kadar TNF α, nilai HOMA-IR dan pelemakan hati sederhana nonalkoholik pada pelajar SMA dengan obesitas. J Indon Med Assoc. 2013;63(1)27-31.

Nasution IR, Setiati S, Trisnohadi HB, Oemardi M. Insulin resistance and metabolic syndrome in elderly women living in nursing homes. Acta Med Indones. 2006;38(1):1-6.

Sun X, Tan J, Zhu Y, Lin L. Association between diabetes mellitus and gastroesophageal reflux disease: A meta-analysis. World J Gastroenterol. 2015;21(10): 3085-92.

Abdullah M, Makmun D, Syam AF, et al. Prevalence, risk factors and socio-epidemiological study of gastroesophageal reflux disease: An urban population based study in Indonesia. Asian J Epidemiol. 2016;9(1-3):18-23.

Syam AF, Hapsari F, Makmun D. The prevalence and risk factors of GERD among Indonesian medical doctors. Makara J Health Res. 2016;20(2):35-40.

Nwokediuko SC. Current trends in the management of gastroesophageal reflux disease: A review. ISRN Gastroenterol. 2013:1-11.

Herbella F, Patti MG. Gastroesophageal reflux disease: From pathophysiology to Treatment. World J Gastroenterol. 2010;16(30):3745-9.

Park JH, Park DI, Kim HJ, et al. Metabolic syndrome is associated with erosive esophagitis. World J Gastroenterol. 2008;14(35):5442-7.

Wu P, Ma L, Dai GX, et al. The association of metabolic syndrome with reflux esophagitis: a case-control study. Neurogastroenterol Motility. 2011;23(11):989-94.

Punjabi P, Hira A, Prasad S, et al. Review of gastroesophageal reflux disease (GERD) in the diabetic patient. Journal of Diabetes 2015; 7:599–609.

Lee SD, Keum B, Chun HJ, Bak YT. Gastroesophageal reflux disease in type II diabetes mellitus with or without peripheral neuropathy. J Neurogastroenterol Motil. 2011;17:274-8.

Krishnan B, Babu S, Walker J, Walker AB, Pappachan JM. Gastrointestinal complications of diabetes mellitus. World J Diabetes. 2013;4 (3):51-63.

Rayner CK, Samsom M, Jones K, Horowitz M. Relationships of upper gastrointestinal motor and sensory function with glycemic control. Diab Care. 2001;24(2):371-81.

The American Association of Clinical Endocrinologists. AACE Position Statement on the Insulin Resistance syndrome. Endocr Pract. 2003:9(3):240-9.

Nam SY, Choi IJ, Ryu KH, et al. The effect of abdominal visceral fat, circulating inflammatory cytokines and leptin levels on reflux esophagitis. J Neurogastroenterol Motil. 2015;21(2):247-52.

Rieder F, Biancani P, Hatnett K, Yerian L, Falk GW. Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis. Am J Physiol Gastrointest Liver Physiol. 2010;298(5):G571–G81.

Ming Tai C, Chia Lee Y, Pin Tu H, et al. The relationship between visceral adiposity and the risk of erosive esophagitis in severely obese chinese patients. Obesity. 2010;18:2165–9.

Caro SD, Cheung WH, Fini L, et al. Role of body composition and metabolic profile in Barrett’s oesophagus and progression to cancer. Eur J Gastroenterol Hepatol. 2016;28(3):251–60.

Hsu CS, Wang PC, Chen JH, et al. Increasing insulin resistance is associated with increased severity and prevalence of gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2011;34:994-1004.

Pointer SD, Ricktrew J, Slaughter JC, et al. Dietary carbohydrate intake, insulin resistance and gastro-oesophageal reflux disease: a pilot study in european-and african-american obese women. Aliment Pharmacol Ther. 2016;44:976–88.

Fujiwara M, Eguchi Y, Fukomori N, et al. The symptoms of gastroesophageal reflux disease correlate with high body mass index, the aspartate Aminotransferase/Alanine Aminotransferase Ratio and Insulin Resistance in Japanese Patients with Non-alcoholic Fatty Liver Disease. Intern Med. 2015;54:3099-104.

Ivashkin V, Evzyustina Y, Trukhmanoz, et al. Systemic inflammatory response in patients with gastroesophageal reflux disease. Am J Clin Med Res. 2015;3(4):64-9.

Savage DB, Petersen KF, Shulman GI. Mechanisms of insulin resistance in humans and possible links with inflammation. Hypertension. 2005;45:828-33.

Fernandez JM, Vayreda M, Richart C, et al. Circulating interleukin 6 levels, blood pressure and insulin sensitivity in apparently healthy men and woman. J CLin Endocrinol Metab. 2001;86:1154-9.

Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest 2006;116:1793-8.


Full Text: PDF

Refbacks

  • There are currently no refbacks.


Copyright (c) 2019 Acta Medica Indonesiana