Role of Desmoglein Autoantibody in the Diagnosis of Pemphigus Vulgaris: A Case Report

Authors

  • Diane Lukito Setiawan Clinical Pathology Sub-Specialization Program, Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo Hospital, Surabaya, Indonesia.
  • Munawaroh Fitriah Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo Hospital, Surabaya, Indonesia
  • Awalia Awalia Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo Hospital, Surabaya, Indonesia

Keywords:

Pemphigus vulgaris, autoantibody, desmoglein

Abstract

Pemphigus vulgaris (PV) is a group of autoimmune diseases that cause abnormalities in the form of lesions or blisters on the skin and mucous membranes. It often presents diagnostic challenges due to its varied clinical manifestations. Accurate diagnosis and treatment are essential to reduce mortality in patients with PV. Traditional diagnostic methods, such as histopathology and direct immunofluorescence, may not always provide conclusive results, especially if the patient does not have an intact bulla. Our report emphasizes the role of desmoglein autoantibody testing using enzyme-linked immunosorbent assay to confirm the diagnosis, allowing for prompt and targeted therapeutic interventions.

Author Biographies

Diane Lukito Setiawan, Clinical Pathology Sub-Specialization Program, Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo Hospital, Surabaya, Indonesia.

1. Clinical Pathology Sub-Specialization Program, Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo Hospital, Surabaya, Indonesia. 2. Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo Hospital, Surabaya, Indonesia.

Munawaroh Fitriah, Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo Hospital, Surabaya, Indonesia

Department of Clinical Pathology, Faculty of Medicine Universitas Airlangga, Dr. Soetomo Academic Hospital, Surabaya, Indonesia

Awalia Awalia, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo Hospital, Surabaya, Indonesia

Department of Internal Medicine, Faculty of Medicine Universitas Airlangga, Dr. Soetomo Academic Hospital Surabaya, Indonesia

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Published

2025-07-08

How to Cite

Setiawan, D. L., Fitriah, M., & Awalia, A. (2025). Role of Desmoglein Autoantibody in the Diagnosis of Pemphigus Vulgaris: A Case Report. Acta Medica Indonesiana, 57(2), 246. Retrieved from http://www.actamedindones.org/index.php/ijim/article/view/2837

Issue

Vol. 57 No. 2 (2025): Acta Medica Indonesiana

Section

CASE REPORT

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Copyright (c) 2025 Diane Lukito Setiawan, Munawaroh Fitriah, Awalia Awalia

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