The Role of Reed-Sternberg CD30 Receptor and Lymphocytes in Pathogenesis of Disease and Its Implication for Treatment
Hodgkin lymphoma is a cancer that can be cured using standard chemotherapy with or without radiation. Although it accounts for only 0.6% of all malignancy worldwide, but it usually affects young adults with median age of 38 years. About 60 to 90% cases can be cured depending on its stage and 5 to 10% cases are refractory to the first-line chemotherapy; while 20 to 30% patients experiencing relapse after receiving the first-line chemotherapy. The relapse causes new problem in treatment. A monoclonal antibody-chemotherapy conjugate, Brentuximab vedotin, was approved by Food Drug Association and European Medicine since 2011 dan was approved by European Medicine Agency since 2012 to treat relapsed classical Hodgkin lymphoma and anaplastic large cell lymphoma (ALCL). Brentuximab vedotin has also been known as anti-CD30.
CD30 or Ki-1 or TNFRSF8 is a 120-kD glycoprotein, which is a trans-membrane receptor of Hodgkin lymphoma cells. The glycoprotein was first identified in 1982 using monoclonal antibody against Hodgkin lymphoma-derived cell lines. The glycoprotein was then cloned and recognized as a member of tumor necrosis factor receptor (TNFR) superfamily, which has intracellular, transcellular and extracellular domains. The monoclonal antibody obviously does cause a reaction not only with the Reed-Sternberg (RS) cells of Hodgkin lymphoma, but also with a small number of normal lymphocytes subset, which are located at perifollicular zone as well as lymphoid tumor such as anaplastic large cell lymphoma (ALCL) and other non-lymphoid tumor such as embryonic and pancreas carcinoma, undifferentiated nasopharyngeal carcinoma and malignant melanoma. Therefore, CD30 monoclonal antibody alone to confirm the diagnosis of Hodgkin lymphoma is ineffective as it must be used together with other panel of immunohistochemistry antibodies such as cytokeratins, carcinoma embryonic antigen, melanoma-associated antigen and placental alkaline phosphatide.
The expression of CD30 molecules in Reed-Sternberg cells of Hodgkin lymphoma has been demonstrated in over 98% of classical Hodgkin lymphoma cases; however, there is a difference in staining intensity among various cases or even in one case.
PopoviÄ‡ L, JovanoviÄ‡ D, PopoviÄ‡ D. CD30 - The head of TNF-family or a successful story of brentuximab vedotin. Arch Oncol. 2013;21(1):17â€“9.
Jona A, Szodoray P, IllÃ©s A. Immunologic pathomechanism of Hodgkinâ€™s lymphoma. Exp Hematol. 2013;41(12):995â€“1004.
Weyden CA Van Der, Pileri SA, Feldman AL, Whisstock J, Prince HM. Understanding CD30 biology and therapeutic targeting : a historical perspective providing insight into future directions. Nat Publ Gr [Internet]. 2017;(April):1â€“10.
Flangea C, Potencz E, MihÇŽescu R, et al. CD30 expression utilization for the accuracy of classical Hodgkinâ€™s lymphoma staging. Rom J Morphol Embryol. 2006;47(2):113â€“7.
Testing D, Therapy T. Clinical roundtable monograph CD30 in lymphoma: Its role in biology, diagnostic testing, and targeted therapy discussants. 2014;(April).
Agostinelli C, Pileri S. Pathobiology of Hodgkin lymphoma. Mediterr J Hematol Infect Dis. 2014;6(1).
Clinical N, Guidelines P, Guidelines N, Guidelines N. Hodgkin Lymphoma. 2018.
Eichenauer DA, Engert A, Federico M, Illidge T, Hutchings M, Ladetto M. clinical practice guidelines Hodgkinâ€™s lymphoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Clinical Practice Guidelines. 2018;25(June).
Fadhil MS, Al-nueimy WM, Lazim AF. Hodgkinâ€™s lymphoma. 2014;35(5):448â€“53.
Tarkowski M. Expression and function of CD30 on T lymphocytes. Arch Immunol Ther Exp (Warsz) [Internet]. 1999;47:217â€“21.
Shooshtarizadeh T, Mohammadali A, Ossareh S, Ataipour Y. Relation between pretransplant serum levels of soluble CD30 and acute rejection during the first 6 months after a kidney transplant. Exp Clin Transplant. 2013;11(3):229â€“33.
SÃ¼sal C, Pelzl S, DÃ¶hler B, Opelz G. Identification of highly responsive kidney transplant recipients using pretransplant soluble CD30. J Am Soc Nephrol. 2002;13(6):1650â€“6.
Amirzargar MA, Amirzargar A, Basiri A, et al. Early post-transplant immune monitoring can predict long-term kidney graft survival: Soluble CD30 levels, anti-HLA antibodies and IgA-anti-Fab autoantibodies. Hum Immunol. 2014;75(1):47â€“58.
Rojas-Ramos E, Garfias Y, JimÃ©nez-MartÃnez MDC, et al. Increased expression of CD30 and CD57 molecules on CD4+ T cells from children with atopic asthma: A preliminary report. Allergy Asthma Proc. 2007;28(6).
Polte T, Behrendt AK, Hansen G. Direct evidence for a critical role of CD30 in the development of allergic asthma. J Allergy Clin Immunol. 2006;118(4):942â€“8.
Foks AC, Bot I, Frodermann V, et al. Interference of the CD30-CD30L pathway reduces atherosclerosis development. Arterioscler Thromb Vasc Biol. 2012;32(12):2862â€“8.
Business Wire. Seattle genetics initiates clinical trial of ADCETRISÂ® (Brentuximab Vedotin) in systemic lupus erythematosus, a chronic autoimmune disease [Internet]. 2015. Available from: http://www.businesswire.com/news/home/20150709005274/en/Seattle-Genetics-Initiates-Clinical-Trial-ADCETRISÂ®-Brentuximab.
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