The Benefit of Interferon-Gamma Release Assay for Diagnosis of Extrapulmonary Tuberculosis
Keywords:
extrapulmonary TB, IGRA, histopathology, tissue acid-fast bacilliAbstract
Background: there are many researches about IGRA in extrapulmonary Tuberculosis (TB), but there only few data from developing countries. This was the first research about the utility of IGRA in extrapulmonary TB performed in Indonesia as developing country with the 2nd most frequent of TB cases in the world. This study aimed to identify the advantage of IGRA examination in diagnosing extrapulmonary TB. Methods: eighty-four patients, presumed to have extrapulmonary TB were examined with IGRA and gold standard examination. The gold standard examination was performed by histopathologic examination, and tissue smear for acid-fast bacilli. Results: among 84 patients included in the study, 57 patients were tested positive with gold standard, where 50 patients among them were also tested positive with IGRA. Among 27 patients tested negative with gold standard, IGRA positive was found in 10 patients. Lymphadenitis was the most common manifestation of the extrapulmonary TB. Diagnostic test from IGRA for extrapulmonary TB found as follows: sensitivity 87,71%, specificity 63%, positive predictive value 83,33%, and negative predictive value 70,83%. Conclusion: IGRA could be used as supporting tool in the diagnosis of extrapulmonary TB. The negative result, however, does not indicate absence of TB infection.References
Tuberculosis disease burden. Global Tuberculosis Report 2017.Geneva :World Health Organization; 2017.
Tatar D, Senol G, Alptekin S, Gunes E, Aydin M, Gunes O. Assessment of extrapulmonary tuberculosis in two provinces of Tukey. Iran J Public Health. 2016; 45: 305-13.
Lapausa M, Saldana AM, Asensio AN. Extrapulmonary tuberculosis : an overview. Rev Esp Sanid Penit. 2015; 17: 3-11.
Kulchavenya E. Extrapulmonary tuberculosis : are statistical report accurate ? Ther Adv Infect Dis. 2014; 2: 61-70.
Wani RLS. Clinical manifestations of pulmonary and extrapulmonary tuberculosis. South Sudan Medical Journal. 2013; 3: 52-6.
Gomes T, Vinhas SA, Santos BR, Palaci M, Peres RL, Agular PP, et al. Extrapulmonary tuberculosis : Mycobacterium tuberculosis strain and host risk factor in a large urban setting in Brazil. PLOS ONE. 2013; 8: 1-9.
TB CARE I. International Standard for Tuberculosis Care. Edition 3.. TB CARE I, The Hague, 2014.
Lewinsohn DM, Leonard MK, LoBue PA, Cohn DL, Daley CL, Desmond E, et al. Official American Thoracic Society/Infectious Disease Society of America/ Centers for Disease Control and Prevention Clinical Practice Guidelines : Diagnosis of Tuberculosis in Adults and Children. Clinical Infectious Disease. 2017; 64: e8-e24.
Lee JY. Diagnosis and treatment of extrapulmanary tuberculosis. Tuberc Respir Dis. 2015; 78: 47-55.
Yun F, Ni D, Lingyun S, Jing W, Shu Z, Jialin J, et al. Interferon-gamma release assay performance in pulmonary and extrapulmonary tuberculosis. Plos ONE. 2012; 7: 1-7.
Cho OH, Park KH, Kim SM, Park SJ, Moon SM, Chong YP, et al. Diagnostic performance of T-SPOT.TB for extrapulmonary tuberculosis according to site of infection. Journal of Infection. 2011; 63: 362-9.
Kobashi Y, Sugiu T, Mouri K, Obase Y, Miyashita N, Oka M. Indeterminate result of Quantiferon TB-2G test performed in routine clinical practice. Eur Respir J. 2009; 33: 812-5.
Jeong SJ, Han SH, Kim CO, Baek JH, Jin SJ, Ku NS, et al. Predictive factors for indeterminate result on the QuantiFERON test in an indeterminate tuberculosis-burden country. J Infect. 2011; 62: 347-54.
Lin F, Zhou C, Xiao-Hui H, Zhong-Yi Hu, He-Ping X. Interferon-gamma release assays for the diagnosis of extrapulmonary tuberculosis : a systematic review and meta-analysis. FEMS Immunol Med Microbiol. 2012; 1-11.
Shin JA, Chang YS, Kim HJ, Ahn CM, Byun MK. Diagnostic utility of interferon-gamma release assay in extrapulmonary tuberculosis. Diagnostic Microbiology and Infectious Disease. 2015; 82: 44-8.
Adilistya T, Astrawinata DAW, Nasir UZ. Use of pleural fluid interferon-gamma enzyme-linked immunospot assay in the diagnosis of pleural tuberculosis. Acta Medica Indonesiana. 2016; 48: 41-7.
Xiao XZ, Ya LL, Kan Z, Huan ZS, Zhao HT. Body fluid interferon-γ release assay for diagnosing of extrapulmonary tuberculosis in adults : A systematic review and meta-analysis.[Cited October 27 2015]. Available from: http://www.nature.com/scientificreports.
Qianqian L, Wenzhang L, Yunfeng C, Xinmiao D, Chengdi W, Binmiao L, et al. Performance of interferon-γrelease assay in the diagnosis of tuberculous lymphadenitis : a meta-analyisis. PeerJ. 2017; 1-14.
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