Investigating Elevated E-Selectin and P-Selectin Levels in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Patients: The Stepping Stone to a Future Clinical Approach

Authors

  • Syntia Nusanti 1. Doctoral Program in Medical Science, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia. 2. Neuro-ophthalmology Division, Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
  • Andhika Rachman Hematology and Medical Oncology Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
  • Brigitta Marcia Budihardja Residency Program in Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia
  • Lourisa Ruth Eldinia Residency Program in Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia
  • Nadia Delima Andini Research Assistant, Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia
  • Arief Kartasasmita Vitreoretina Division, Department of Ophthalmology, Faculty of Medicine Padjajaran University – Cicendo Eye Hospital, Bandung, Indonesia
  • M Sidik Neuro-ophthalmology Division, Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
  • Seskoati Prayitnaningsih Neuro-ophthalmology Division, Department of Ophthalmology, Faculty of Medicine Brawijaya University –Saiful Anwar General Hospital, Malang, Indonesia
  • Alida Roswita Harahap Doctoral Program in Medical Science, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia
  • Aria Kekalih Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
  • Tjahjono Darminto Gondhowiardjo 1. Doctoral Program in Medical Science, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia. 2. Cataract and Refractive Surgery Division, Department of Ophthalmology, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Keywords:

non-arteritic anterior ischemic optic neuropathy, NAION, e-selectin, p-selectin, hypercoagulation

Abstract

Background: Studies regarding hypercoagulation in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) patients have produced conflicting results. With a presumption that the early coagulation phase may affect the occurrence of NAION, this study aims to investigate the early coagulation markers, E-selectin and P-selectin, to determine whether these biomolecular changes play a significant role in NAION, thus potentially leading to a better clinical approach. Methods: A cross-sectional study involving two groups of NAION subjects, a hypercoagulation group and a non-hypercoagulation group, was conducted in the Neuro-Ophthalmology Division, Department of Ophthalmology, FKUI-RSCM Kirana from October 2020 to April 2022. All patients were evaluated for E-selectin and P-selectin levels measured using flow cytometry.  Results: A total of 42 subjects comprising 14 hypercoagulation and 28 non-hypercoagulation subjects were included. In all subjects, E-selectin was strongly correlated with P-selectin (r = 0.862, p < 0.001). There was no significant difference in E-selectin and P-selectin values between the groups (p = 0.317 for E-selectin, and p = 0.575 for P-selectin). Prothrombin time and international normalized ratio (INR) were inversely correlated with both E-selectin and P-selectin in the hypercoagulation group (p = 0.032, p = 0.030 for E-selectin and p = 0.044, p = 0.036 for P-selectin). There was no significant correlation between E-selectin and P-selectin for NAION-associated metabolic risk factors. However, higher E-selectin and P-selectin values were found in the presence of risk factors except for P-selectin in the hypertension group. Conclusion: This interesting finding opens up the potential for considering the involvement of E-selectin and P-selectin in the diagnostic strategy for NAION. It prompts consideration of whether assessing E-selectin and P-selectin levels should be recommended for all NAION patients. Furthermore, considering the role of E-selectin and P-selectin in the early coagulation process, future studies are also needed to further evaluate whether anticoagulants could play a role in the choice of treatment for NAION despite a clinically hypercoagulable state.

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Published

2025-01-21

How to Cite

Nusanti, S., Rachman, A., Budihardja, B. M., Eldinia, L. R., Andini, N. D., Kartasasmita, A., Sidik, M., Prayitnaningsih, S., Harahap, A. R., Kekalih, A., & Gondhowiardjo, T. D. (2025). Investigating Elevated E-Selectin and P-Selectin Levels in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Patients: The Stepping Stone to a Future Clinical Approach. Acta Medica Indonesiana, 56(4), 445. Retrieved from http://www.actamedindones.org/index.php/ijim/article/view/2581

Issue

Vol. 56 No. 4 (2024): Acta Medica Indonesiana

Section

ORIGINAL ARTICLE

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