The Profile of COVID-19 in Patients with Autoimmune Disease: A Case Series
Keywords:
autoimmune diseases, COVID-19, case series, IndonesiaAbstract
Autoimmune diseases are known to be a risk factor for severe COVID-19 infection. This is the first case series of patients with autoimmune disease suffering from COVID-19 infection in Jakarta, Indonesia. There were 12 confirmed cases of COVID-19 infection in autoimmune patients from March 2020 until February 2021. We select 5 patients in this case series. Three of them had systemic lupus erythematous (SLE), one of them had rheumatoid arthritis, and one of them had ankylosing spondylitis. Three of them had high BSR Risk Stratification. Most of them had used daily steroid therapy. Fatigue, abdominal pain, diarrhea, and cough were the common symptoms found. None of the patients were admitted to ICU, used mechanical ventilators, and all of them survived. Most of the patients were prescribed anti-coagulant therapy. This first comprehensive case series can provide valuable information regarding the clinical characteristics of COVID-19 infection in the Indonesian autoimmune disorder patient population.References
Organization WH. Coronavirus16 February 2021]. Available from: https://www.who.int/health-topics/coronavirus.
Nasional. KPC-dPE. Peta Sebaran16 February 2021]. Available from: https://covid19.go.id/peta-sebaran.
Alharthy A, Faqihi F, Nasim N, et al. COVID-19 in a patient with a flare of systemic lupus erythematosus: A rare case-report. Respiratory Medicine Case Reports. 2020;31:101252.
Gartshteyn Y, Askanase AD, Schmidt NM, et al. COVID-19 and systemic lupus erythematosus: a case series. The Lancet Rheumatology. 2020;2(8):e452-e4.
Furer V, Rondaan C, Heijstek MW, et al. 2019 update of EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases. Annals of the rheumatic diseases. 2020;79(1):39-52.
Smith DA, Germolec DR. Introduction to immunology and autoimmunity. Environmental health perspectives. 1999;107 Suppl 5:661-5.
Fung SY, Yuen KS, Ye ZW, Chan CP, Jin DY. A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses. Emerging Microbes & Infections. 2020;9(1):558-70.
RI KK. Hari Lupus Sedunia 2018: Memahami Program Deteksi Dini Penyakit Lupus Eritematosus Sistemik (LES)16 February 2021]. Available from: http://p2p.kemkes.go.id/hari-lupus-sedunia-2018-memahami-program-deteksi-dini-penyakit-lupus-eritematosus-sistemik-les/.
PDPI, PERKI, PAPDI, PERDATIN, IDAI. Pedoman Tatalaksana COVID-19 December 2020.
Chattopadhyay A, Mishra D, Sharma V, Naidu GSK, Sharma A. Coronavirus disease-19 and rheumatological disorders: A narrative review. Indian J Rheumatol. 2020;15(2):8.
Force ADT, Ranieri VM, Rubenfeld GD, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012;307(23):2526-33.
Maddur MS, Vani J, Lacroix-Desmazes S, Kaveri S, Bayry J. Autoimmunity as a predisposition for infectious diseases. PLoS Pathogens. 2010;6(11):e1001077.
Fernandez-Ruiz R, Paredes JL, Niewold TB. COVID-19 in patients with systemic lupus erythematosus: lessons learned from the inflammatory disease. Translational Research: the Journal of Laboratory and Clinical Medicine. 2020.
Pablos JL, Abasolo L, Alvaro-Gracia JM, et al. Prevalence of hospital PCR-confirmed COVID-19 cases in patients with chronic inflammatory and autoimmune rheumatic diseases. Annals of The Rheumatic Diseases. 2020;79(9):1170-3.
Akiyama S, Hamdeh S, Micic D, Sakuraba A. Prevalence and clinical outcomes of COVID-19 in patients with autoimmune diseases: a systematic review and meta-analysis. Annals of the Rheumatic Diseases. 2020.
Murray K, Quinn S, Turk M, et al. COVID-19 and rheumatic musculoskeletal disease patients: infection rates, attitudes and medication adherence in an Irish population. Rheumatology. 2021;60(2):902-6.
Zen M, Fuzzi E, Astorri D, et al. SARS-CoV-2 infection in patients with autoimmune rheumatic diseases in northeast Italy: A cross-sectional study on 916 patients. Journal of Autoimmunity. 2020;112:102502.
Landewe RB, Machado PM, Kroon F, et al. EULAR provisional recommendations for the management of rheumatic and musculoskeletal diseases in the context of SARS-CoV-2. Annals of the Rheumatic Diseases. 2020;79(7):851-8.
Haberman R, Axelrad J, Chen A, et al. COVID-19 in Immune-Mediated Inflammatory Diseases - Case Series from New York. The New England Journal of Medicine. 2020;383(1):85-8.
Hidayat R, Isbagio H, Ariane A, et al. Characteristics of patients with autoimmune rheumatic disease in the era of COVID-19 pandemic in Indonesia. IJR. 2020;12(1):8.
Low JG, Lee CC, Leo YS, Low JG, Lee CC, Leo YS. Severe acute respiratory syndrome and pulmonary tuberculosis. Clinical Infectious Diseases. 2004;38(12):e123-5.
Abadom TR, Smith AD, Tempia S, Madhi SA, Cohen C, Cohen AL. Risk factors associated with hospitalisation for influenza-associated severe acute respiratory illness in South Africa: A case-population study. Vaccine. 2016;34(46):5649-55.
Visca D, Ong CWM, Tiberi S, et al. Tuberculosis and COVID-19 interaction: A review of biological, clinical and public health effects. Pulmonology. 2021;27(2):151-65.
Gianfrancesco M, Hyrich KL, Al-Adely S, et al. Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry. Annals of the Rheumatic Diseases. 2020;79(7):859-66.
Strangfeld A, Schafer M, Gianfrancesco MA, et al. Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry. Annals of the Rheumatic Diseases. 2021.
Downloads
Published
How to Cite
Issue
Section
License
Copyright
The authors who publish in this journal agree to the following requirements:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors can enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) before and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work. (See The Effect of Open Access)
Privacy Statement
The names and email addresses entered in this journal site will be used exclusively for the stated purposes of this journal and will not be made available for any other purpose or to any other party.
