Comparison of Asymmetric Dimethylarginine Levels Between Stages Three, Four, and Five Non-dialysis of Chronic Kidney Disease

Tri P Asmarawati, Widodo Widodo, M Thaha, Aditiawardana Aditiawardana, Nunuk Mardiana, Ardityo R Ardhany, Artaria Tjempakasari, Djoko Santoso, Pranawa Pranawa, Chandra Irwanadi

Abstract


Aim: to determine the differences of ADMA level between stages 3, 4, and 5 non-dialysis of chronic kidney
disease (CKD) patients at Outpatient Nephrology Clinic, Dr. Soetomo Hospital. Methods: a cross-sectional
study was conducted on stage 3, 4, and 5 non-dialysis CKD patients at Outpatient Nephrology Clinic, Dr.
Soetomo Hospital, Surabaya from January to February 2015. Stages of CKD were determined based on GFR
estimation according to 4-variable MDRD formula. Statistical analysis of differences in the levels of ADMA in
three subject groups use one-way ANOVA test. Results:seventy-five patients were included in the study. Each
group consisted of 25 patients stage 3, 4, and, 5 non-dialysis patients. Mean age of stage 3, stage 4, and stage
5 non-dialysis CKD patients were respectively 57.12 years, 54.80 years and 53.68 years. The mean levels of
ADMA in stage 3, stage 4, and 5 were 0.62 (0.11) IU/mL, 0.72 (0.16) IU/mL, and 0.73 (0.18) IU/mL respectively.
Analysis of the differences between the groups showed significant differences in ADMA levels (p=0.04), with the
highest difference between stage 3 and stage 5. Conclusion:comparison of ADMA levels showed significant
differences between CKD stages and the level tends to be higher along with increase severity of CKD stages.

Keywords


chronic kidney disease; asymmetric dimethylarginine (ADMA); cardiovascular disease

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