Influence of Micronutrient Consumption by Tuberculosis Patients on the Sputum Conversion Rate: A Systematic Review and Meta-analysis Study

Putri Bungsu Machmud, Ratna Djuwita, Dwi Gayatri, Nurul Khairani, Wahyu K.Y. Putra, Sudarto Ronoatmodjo

Abstract


Background: infectious disease is one of the global health challenge in the world, including tuberculosis. Some factors significantly associated with increased treatment success, including the duration of treatment or treatment compliance, use more than three sensitive drugs, individualized regimen, and weight-related to micronutrient. Methods: a systematic review and meta-analysis study of randomized control trial studies conducted and reported by preferred reporting items for systematic reviews and meta-analyses. The primary data source was online publications, consist of three bases data, which subscribed by Universitas Indonesia, they are Proquest, EBSCO CINAHL, EBSCO Dentistry. Risk of bias was assessed using the Cochrane risk-of-bias tool, and data were analyzed using Review Manager 2015. Results: there were eight full paper rates as relevant studies. There was a significant difference of effect among the intervention group compared the control group (or placebo group). RR of the pooled estimate was 1.12 (95% CI: 1.06 - 1.18) with heterogeneity study 36%. While, the poled calculated based on type of micronutrient from seven studies showed there was no difference of sputum conversion between Vitamin D and placebo group (RR-1.05, 95% CI 0.99 – 1.12) with heterogeneity study 0% and a significant result seems among Zinc and Retinol intervention (RR=1.21, 95% CI 1.09 – 1.35) with heterogeneity study 40%. Conclusion: micronutrient intervention during tuberculosis treatment has a positive effect toward to sputum conversion among patient. Zinc and retinol influence sputum conversion while vitamin D did not.

Keywords


tuberculosis; infectious disease; micronutrient consumption; sputum conversion

References


WHO. Global Tuberculosis Report 2018. Geneva: WHO; 2018.

WHO. Global Tuberculosis Report 2015. Geneva: WHO; 2015.

WHO. Global Tuberculosis Report 2016. Geneva: WHO; 2016.

WHO. Global Tuberculosis Report 2017. Geneva: WHO; 2017.

Lawn SD, Zumla AI. Tuberculosis. Lancet. 2011;378:57-72.

Weiss P, Chen W, Cook VJ, Johnston JC. Treatment outcomes from community-based drug-resistant tuberculosis treatment programs: a systematic review and meta-analysis. BMC Infect Dis. 2014;14(333):1-9.

Gegia M, Winters N, Benedetti A, Soolingen DV, Menzies D. Treatment of isoniazid-resistant tuberculosis with first-line drugs: a systematic review and meta-analysis. Lancet Infect Dis. 2017;17:223-34.

Akçakır Y. Correlates of treatment outcomes of Multidrug Resistant Tuberculosis (MDR-TB): a systematic review and meta-analysis. Quebec, Canada: McGill University; 2009.

Jimma W, Ghazisaeedi M, Shahmoradi L, et al. Prevalence of and risk factors for multidrug-resistant tuberculosis in Iran and its neighboring countries: systematic review and meta-analysis. Rev Soc Bras Med Trop. 2017;50(9):287-95.

Farley JE, Ram M, Pan W, et al. Outcomes of multi-drug resistant Tuberculosis (MDR-TB) among a cohort of South African patients with high HIV prevalence. PLoS ONE. 2011;6(7):1-7.

Karyadi E, Schultink W, Nelwan RHH, et al. Poor micronutrient status of active pulmonary tuberculosis patients in Indonesia. J Nutr. 2000;130:2953-8.

Podewils LJ, Holtz T, Riekstina V, et al. Impact of malnutrition on clinical presentation, clinical course, and mortality in the MDR-TB patient. Epidemiol Infect. 2010;139:113-2.

Feleke BE, Alene GD, Feleke TE, Motebaynore Y, Boadglegne F. Clinical response of tuberculosis patients, a prospective cohort study. PLoS ONE. 2017:1-11.

Magee MJ, Sun YV, Brust JC, et al. Polymorphisms in the vitamin D receptor gene are associated with reduced rate of sputum culture conversion in multidrug-resistant tuberculosis patient in South Africa. Plos One. 2017;12(7):1-11.

Shamseer L, Moher D, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (8) 2015 statement. BMJ. 2015;349:1-25.

Wells G, Shea B, O’Conell D, et al. The newcastle-ottawa scale (NOS) for the quality of nonrandomized studies in meta-analysis Canada: www.ohri.ca; 2014.

Afzal A, Rathore R, Butt NF, Randhawa FA. Efficacy of Vitamin D supplementation in achieving an early sputum conversion in smear-positive Pulmonary Tuberculosis. Pakistan J Med Sci Quarter. 2018;34(10):849-54.

Armijos RX, Weigel MM, Chacon R, Flores L, Campos A. Adjunctive micronutrient supplementation for pulmonary tuberculosis. Salud Publica de Mexico. 2010;52(9):185-9.

Jahnavi G, Sudha C. Randomised controlled trial of food supplementation in patients with newly diagnosed tuberculosis and wasting. Singapore Med. 2010;51(12):957-62.

Lawson L, Thacher TD, Yassin MA, et al. Randomized controlled trial of zinc and vitamin A as con-adjuvants for the treatment of pulmonary tuberculosis. Trop Med Int Health. 2010;15(12):1481-90.

Martineau AR. Old wine in new bottles: vitamin D in the treatment and prevention of tuberculosis. The Proceedings of the Nutrition Society. 2012;71(1):84-9.

Pakasi TA, Karyadi E, Suratih NMD, et al. Zinc and vitamin A supplementation fails to reduce sputum conversion time in severely malnourished pulmonary tuberculosis patients in Indonesia. Nutritional J. 2010;9(41):1-10.

Masood KI, Rottenberg ME, Salahuddin N, et al. Expression of M. tuberculosis-induced suppressor of cytokine signaling (SOCS) 1, SOCS3, FoxP3 and secretion of IL-6 associates with differing clinical severity of tuberculosis. BMC Infect Dis. 2013;13:13.

Tukvadze N, Sanikidze E, Kipiani M, et al. High-dose vitamin D3 in adults with pulmonary tuberculosis: a double-blind, randomized controlled trial. Am J Clin Nutr. 2015;102:1059-69.

Qrafli M, Kari KE, Aguenaou H, Bourkadi JE, Sadki K, Mzibri ME. Low plasma vitamin A concentration is associated with tuberculosis in Moroccan population: a preliminary case-control study. BMC Res Notes. 2017;10:1-6.

Ganmaa D, Munkhzul B, Fawzi W, et al. High-dose vitamin D3 during tuberculosis treatment in Mongolia: A randomized controlled trial. Am J Resp Crit Care Med. 2017;196(5):628-37.

Wu H-x, Xiong X-f, Zhu M, Wei J, Zhuo K-q, Cheng D-y. effects of vitamin D supplementation on the outcomes of patients with pulmonary tuberculosis: a systematic review and meta-analysis. BMC Pulmonary Med. 2018;18(108).

Skodric-Trifunovic V, Blanka A, Stjepanovic MI, et al. The health benefits of vitamin D relevant for tuberculosis. J Med Biochem. 2014;33:301-6.


Full Text: PDF

Refbacks

  • There are currently no refbacks.


Copyright (c) 2020 Acta Medica Indonesiana