A Case Report on Cholestatic Jaundice Secondary to Adverse Effect of Phaleria macrocarpa (Mahkota Dewa)

Muhammad Firdaus Abdul Rahim, Alvin Oliver Payus

Abstract


Drug induced cholestatic liver injury can posed a great diagnostic difficulty as a result of its long non-exhaustive list of potential offending causes which can be either prescribed or over-the-counter medications, such as medicinal herbs and remedies. Phaleria macrocarpa, or more commonly known as the ‘God’s crown’ by the local people of South East Asia, is not listed as one of the causes. This medicinal plant extract has been increasingly used for traditional treatment for various ailments. Here, we report a case of a young man who has no known medical illness presented with cholestatic pattern of liver injury which caused by chronic ingestion of Phaleria macrocarpa. The objective of this case report is to share the uncommon side effect of taking this traditional product which may have been under-reported due to the unknown effect.

Keywords


drug induced cholestatic liver injury; cholestasis; Phaleria macrocarpa; Asia

References


Altaf R, Asmawi MZ, Dewa A, Sadikun A, Umar MI. Phytochemistry and medicinal properties of Phaleria macrocarpa (Scheff.) Boerl. extracts. Pharmaco Rev. 2013;7(13):73.

Faried A, Kurnia D, Faried LS, Usman N, Miyazaki T, Kato H, Kuwano H. Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines. Int J Oncol. 2007;30(3):605-13.

Sugiwati S, Kardono L, Bintang M. a-Glucosidase inhibitory activity and hypoglycemic effect of Phaleria macrocarpa fruit pericarp extracts by oral administration to rats. J Appl Sci. 2006;6:2312-6.

Triastuti A, Park HJ, Choi JW. Phaleria macrocarpa suppress nephropathy by increasing renal antioxidant enzyme activity in alloxan-induced diabetic rats. Natural Prod Sci. 2009;15(3):167-72.

Zhang YB, Xu XJ, Liu HM. Chemical constituents from Mahkota dewa. J Asian Natural Prod Res. 2006;8(1-2):119-23.

Sundari N, Soetikno V, Louisa M, Wardhani BW, Tjandrawinata RR. Protective effect of Phaleria macrocarpa water extract (Proliverenol) against carbon tetrachloride-induced liver fibrosis in rats: Role of TNF-α and TGF-β1. J Toxicol. 2018;2018.

Yosie A, Effendy MA, Sifzizul TM, Habsah M. Antibacterial, radical-scavenging activities and cytotoxicity properties of Phaleria macrocarpa (scheff.) Boerl. Leaves in hepg2 cell lines. Int J Phar Sci Res. 2011;2(7):1693.

Sundaram V, Björnsson ES. Drug‐induced cholestasis. Hepatol Comm. 2017;1(8):726-35.


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