The Association of b2-Microglobulin and Fibroblast Growth Factor 23 with Major Adverse Cardiac Event in Acute Coronary Syndrome Patients with Chronic Kidney Disease

Authors

  • Eka Ginanjar Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia
  • Idrus Alwi Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia
  • Aida Lydia Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia
  • Suzanna Immanuel Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia
  • Muhammad Yamin Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia
  • Taufik Indrajaya Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Sriwijaya University, Palembang, Indonesia
  • Kuntjoro Harimurti Division of Geriatric, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Clinical Epidemiology and Evidence-Based Medicine, Cipto Mangunkusumo Hospital, Jakarta, Indonesia

Keywords:

Beta2-Microglobulin, Fibrioblast Growth Factor 23, Acute Coronary Syndrome, Major Adverse Cardiac Event

Abstract

Background: chronic kidney disease (CKD) increases the severity and risk of mortality in acute coronary syndrome (ACS) patients. The role of β2-M as a filtration and inflammation marker and FGF23 as a CKD-MBD process marker might be significant in the pathophysiology in ACS with CKD patients. This study aims to determine the association of β2-M and FGF23 with major adverse cardiac event (MACE) in ACS patients with CKD. Methods: we used cross sectional and retrospective cohort analysis for MACE. We collected ACS patients with CKD consecutively from January until October 2018 at Dr. Cipto Mangunkusumo General Hospital. Data were analyzed using logistic regression and Cox’s Proportional Hazard Regression. Results: a total of 117 patients were selected according to the study criteria. In bivariate analysis, β2-M, FGF23, and stage of CKD had significant association with MACE (p = 0.014, p = 0.026, p = 0.014, respectively). In multivariate analysis, β2-M - but not FGF 23- was significantly associated with MACE (adjusted HR 2.16; CI95% 1.15–4.05; p = 0.017). Conclusion: β2-M was significantly associated with MACE, while FGF23 was not so. This finding supports the role of inflammation in cardiovascular outcomes in ACS with CKD patient through acute on chronic effect.

Author Biographies

Eka Ginanjar, Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia

Staff of Cardiology Division, Department of Internal Medicine

Idrus Alwi, Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia

Professor of Cardiology Division, Department of Internal Medicine

Suzanna Immanuel, Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia

Professor of Cardiology Division, Department of Internal Medicine

Muhammad Yamin, Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia

Staff of Cardiology Division, Department of Internal Medicine

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Published

2021-03-31

How to Cite

Ginanjar, E., Alwi, I., Lydia, A., Immanuel, S., Yamin, M., Indrajaya, T., & Harimurti, K. (2021). The Association of b2-Microglobulin and Fibroblast Growth Factor 23 with Major Adverse Cardiac Event in Acute Coronary Syndrome Patients with Chronic Kidney Disease. Acta Medica Indonesiana, 53(1), 5. Retrieved from https://www.actamedindones.org/index.php/ijim/article/view/999

Issue

Vol. 53 No. 1 (2021): Acta Medica Indonesiana

Section

ORIGINAL ARTICLE

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