The Differences in Serum Quantitative Specific IgE Levels Induced by Dermatophagoides pteronyssinus, Dermatophagoides farinae and Blomia tropicalis Sensitization in Intermittent and Persistent Allergic Asthma
Abstract
Background: house dust mites (HDM) are an important inhalant allergen in allergic asthma. However, molecular diagnostic study of specific IgE to HDM allergens has not been done in Indonesia. In addition, the association of quantitative specific IgE measurement with asthma severity has not been investigatedd. This study aimed to investigate the difference of serum quantitative specific IgE levels induced by Dermatophagoides (D.) pteronyssinus, D. farinae and Blomia tropicalis sensitization in intermittent and persistent allergic asthma.
Methods: this was a cross-sectional study on adult allergic asthma patients who were invited for serum specific IgE testing. This study was a part of a larger study within the Division of Allergy and Immunology, Cipto Mangunkusumo Hospital. Asthma severity was defined based on Global Initiative on Asthma (GINA) 2015 criteria and were grouped as intermittent or persistent. Quantitative specific IgE testing was done on blood serum using a multiple allergosorbent test (Polycheck Allergy, Biocheck GmbH, Munster, Germany). The HDM allergens tested were D. pteronyssinus, D. farinae, and Blomia tropicalis. Difference between two groups were analyze using Mann-Whitney test.
Results: a total of 87 subjects were enrolled in this study; 69 (79.3%) were women. Mean patients’ age was 40, 2 years. Sixty-three (72.4%) subjects had asthma and allergic rhinitis. Fifty-eight (66.7%) subjects were classified as persistent asthma. The prevalence of sensitization was 62.1% for D. farinae, 51.7% for D. pteronyssinus, and 48.3% for Blomia tropicalis. The median of specific IgE levels were significantly higher in persistent asthma compares to intermittent asthma induced by D. farinae (median 1.30 vs. 0.0 kU/L; p=0.024) and B. tropicalis (median 0.57 vs. 0.0 kU/L; p=0.015) sensitization. Level of Specific IgE D. pteronyssinus was also to be higher in persistent asthma than the level measured in intermittent asthma (0.67 vs. 0.00 kU/L; p=0.066).
Conclusion: Sensitization of HDM allergens was shown to be highest for D. farinae 62.1%, followed by D. pteronyssinus 51.7% and Blomia tropicalis 48.3%. Specific IgE level induced by D. farinae and Blomia tropicalis sensitization were significantly higher in patients with persistent asthma compared to intermittent asthma, whereas specific IgE level induced by D. pteronyssinus sensitization was higher in persistent asthma although not statistically significant.
Keywords
References
Brozek JL, Bousquet J, Baena-Cagnani CE, et al. Allergic rhinitis and its impact on asthma (ARIA) guidelines. J Allergy Clin Immunol. 2010;126:466–76.
National Asthma Education and Prevention Program. Expert Panel Report 3: Guidelines for the diagnosis and management of asthma. National Heart, Lung, and Blood Institute, National Institutes of Health. Department of Health and Human Services. Baltimore; 2007.
Yunginger JW, Ahlstedt S, Eggleston PA, et al. Quantitative IgE antibody assays in allergic diseases. J Allergy Clin Immunol. 2000;105:1077-84.
Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med. 2012;18:716-25.
Cox L, Williams B, Sicherer S, et al. Pearls and pitfalls of allergy diagnostic testing: Report from the American College of Allergy, Asthma and Immunology/ American Academy of Allergy, Asthma and Immunology Specific IgE Test Task Force. Ann Allergy Asthma Immunol. 2008;101:580-92.
Li J, Huang Y, Lin X, et al. Influence of degree of specific allergic sensitivity on severity of rhinitis and asthma in Chinese allergic patients. Respir Res. 2011;12:95.
Patelis A, Janson C, Borres MP, Nordvall L, Alving K, Malinovschi A. Aeroallergen and food IgE sensitization and local and systemic inflammation in asthma. Allergy. 2014;69:380-7.
Baquerio S, Russo M, Silva V, et al. Respiratory allergy to Blomia tropicalis: Immune response in four syngeneic mouse strains and assessment of a low allergen dose, short-term experimental model. Respiratory Res. 2010;11:1-11.
Baratawidjaja IR, Baratawidjaja PP, Darwis A, Soo HL, Fook TC, Bee Wah L, Batawidjaja KG. Mites in Jakarta homes. Allergy. 1998;53:1226-7.
Asha’ari ZA, Suhaimi Y, Yusof RA, Rushdan I, Maraina CHC. Comparison of serum specific IgE with skin prick test in the diagnosis of allergy in Malaysia. Med J Malaysia. 2011;66:202–6.
Romanet-Manent S, Charpin D, Magnan A, Lanteaume A, Vervloet D, and the EGEA Cooperative Group. Allergic vs. nonallergic asthma: what makes the difference? Allergy. 2002;57:607-13.
Kumar R, Gupta N, Kanuga J, Kanuga M. A comparative study of skin prick test versus serum specific IgE measurement in Indian patients with bronchial asthma and allergic rinitis. Indian J Chest Dis Allied Sci. 2015;57(2):81-5.
Horwood LJ, Fergusson DM, Shannon FT. Social and familial factors in the development of early childhood asthma. Pediatrics. 1985;75:859-68.
Narita S, Goldblum RM, Watson CS, et al. Environmental estrogens induce mast cell degranulation and enhance IgE-mediated release of allergic mediators. Environ Health Perspect. 2007;115:48-52.
Ozdoganoglu T, Songu M. The burden of allergic rhinitis and asthma. Ther Adv Respir Dis. 2012;6:11-23.
Calabria CW, Dietrich J, Hagan L. Comparison of serum-specific IgE (ImunoCAP) and skin prick test result for 53 inhalant allergens in patients with chronic rinitis. Allergy and Asthma proceeding. 2009;3:386-90.
Ricci G, Capelli M, Miniero R, Zannarini L, Dillon P, Masi M. A comparison of different allergometric tests, skin prick tests, Pharmacia Unicap and ADVIA centaur, for diagnosis of allergic diseases in children. Allergy. 2003;58:38-45.
Baratawidjaja IR, Baratawidjaja PP, Darwis A, et al. Prevalence of allergic sensitization to regional inhalant among allergic patient in Jakarta, Indonesia. Asian Pac J Allergy Immunol.1999;17:9-12.
Sundaru H. House dust mite allergen levels and allergen sensitization as risk factor for asthma among student in Central Jakarta. Med J Indones. 2006;15:55-9.
Vidal C, Lojo S, Juangorena M, Gonzales-Quintela A. Association between asthma and sensitization to allergnes of Dermatophagoides pteronyssinus. J Investig Allergol Clin Immunol. 2016;26:304-9.
Manise M, Bakayoko B, Schleich F, Corhay JL, Louis R. IgE mediated sensitisation to aeroallergens in an asthmatic cohort: relationship with inflammatory phenotypes and disease severity. Int J Clin Pract. 2016;70:596-605.
Gandhi VD, Davidson C, Asaduzzaman M, Nahimey D, Vliagoftis H. House dust mite interactions with airway epithelium: role in allergic airway inflammation. Curr Allergy Asthma Rep. 2013;13:262-70.
Richardson G, Eick S, Jones R. How is the indoor environment related to asthma? Literatur review. J Adv Nurs. 2005;52:328-39.
Erwin EA, Rönmark E, Wickens K, et al. Contribution of dust mite and cat specific IgE to total IgE: relevance to asthma prevalence. J Allergy Clin Immunol. 2007;119:359-65.
Refbacks
- There are currently no refbacks.
This work is licensed under a