The Autoimmune Mechanism in Dengue Hemorrhagic Fever

Authors

  • Soroy Lardo Department of Internal Medicine, Gatot Soebroto Central Army Hospital–Jakarta, Indonesia
  • Marsetyawan HNE Soesatyo Department of Histology and Cellular Biology, Faculty of Medicine, University of Gadjah Mada, Sardjito Central General Hospital, Yogyakarta
  • Juffrie Juffrie Department of Pediatrics, Faculty of Medicine, University of Gadjah mada, Sardjito Central General Hospital, Yogyakarta
  • Sitti Rahmah Umniyati Department of Parasitology, Faculty of Medicine, University of Gadjah Mada, Yogyakarta

Keywords:

Autoimmune, dengue, hemorrhagic fever

Abstract

The immune response of dengue fever/dengue hemorrhagic fever is a series of immunopathogenesis processes starting from viral infection to the target on monocytes and macrophages. It may consequently cause a cascade of viremia in the circulation that stimulates the afferent, efferent, and effector mechanism by the interaction of the humoral and complement system. The cascade results in inflammatory substance that will affect capillary permeability and activate coagulation factors leading to further effects on endothelial level. The mechanism involving pathogenesis of DHF/DSS is still vague. So far, a theory of heterologous infection has been developed, which explains that on second infection, there is subneutralization that induce viral replication. The  autoimmune mechanism development leads to the better understanding of DHF. It also  explains the autoimmune response of the viral infection, which consists of molecular mimicry, bystander activation and viral persistence. The development of the autoimmune pathomechanism is related to the role of  autoantibody and endothelial dysfunction that may have role in worsening DHF.

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Published

2018-04-20

How to Cite

Lardo, S., Soesatyo, M. H., Juffrie, J., & Umniyati, S. R. (2018). The Autoimmune Mechanism in Dengue Hemorrhagic Fever. Acta Medica Indonesiana, 50(1), 70. Retrieved from https://www.actamedindones.org/index.php/ijim/article/view/157

Issue

Vol. 50 No. 1 (2018): Acta Medica Indonesiana

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REVIEW ARTICLE

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